Preparation of inactivated poliomyelitis vaccine with attenuated sabin strains.
نویسندگان
چکیده
منابع مشابه
[History of development of the live poliomyelitis vaccine from Sabin attenuated strains in 1959 and idea of poliomyelitis eradication].
In 1958 Poliomyelitis Institute in Moscow and Institute of Experimental Medicine in St. Petersburg received from A. Sabin the attenuated strains of poliomyelitis virus. The characteristics of the strains were thoroughly studied by A. A. Smorodintsev and coworkers. They found that the virulence of the strains fluctuated slightly in 10 consecutive passages through the intestine of the non-immune ...
متن کاملEvolution of the Sabin type 1 poliovirus in humans: characterization of strains isolated from patients with vaccine-associated paralytic poliomyelitis.
Attenuated strains of the Sabin oral poliovirus vaccine replicate in the human gut and in rare cases cause vaccine-associated paralytic poliomyelitis (VAPP). Reversion of vaccine strains toward a pathogenic phenotype is probably one of the main causes of VAPP, a disease most frequently associated with type 3 and type 2 strains and more rarely with the type 1 (Sabin 1) strain. To identify the de...
متن کامل[Paralitic poliomyelitis caused by the oral Sabin vaccine: time for a vaccine change?].
España tiene un sistema nacional de salud descentralizado con larga tradición en atención primaria y es un pilar del estado de bienestar, por lo que la medicina pública es la primera opción de todo médico especializado y, en particular, para los egresados de medicina familiar. El orientarse a la medicina privada es una opción que está más relacionada con retornar a su país o migrar a otro, que ...
متن کاملSafety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: a phase II, randomized, positive-controlled trial.
BACKGROUND The production of Sabin inactivated poliovirus vaccine (IPV) can reduce biosafety requirements in the posteradication/post-oral poliovirus vaccine (OPV) era. We conducted a phase II, randomized, positive-controlled trial to assess the safety and immunogenicity of Sabin IPV. METHODS The test groups (A, B, and C) received 3 doses of high, middle, and low D antigen (D Ag) of Sabin IPV...
متن کاملConcomitant administration of diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine derived from Sabin strains (DTaP-sIPV) with pentavalent rotavirus vaccine in Japanese infants
Rotavirus is the leading cause of severe acute gastroenteritis in infants and young children. Most children are infected with rotavirus, and the health and economic burdens of rotavirus gastroenteritis on healthcare systems and families are considerable. In 2012 pentavalent rotavirus vaccine (RV5) and diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine derived from Sabin...
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ژورنال
عنوان ژورنال: Uirusu
سال: 1986
ISSN: 0042-6857,1884-3433
DOI: 10.2222/jsv.36.125